| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium/hydrogen exchanger 5/H+ exchanger 5 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC9A5 |
| Gene ID: |
6553 |
| Uniprot ID: |
SL9A5_HUMAN |
| Specificity: |
SL9A5 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylated by PRKAA2.promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. |
| Protein Name | Sodium/Hydrogen Exchanger 5Na(+/H(+ Exchanger 5Nhe-5Solute Carrier Family 9 Member 5 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneCell ProjectionDendritic Spine MembraneSynaptic Cell MembraneCell JunctionFocal AdhesionCycles Between Recycling Endosome And Plasma Membrane In Response To Diverse StimuliIts Internalization Is Clathrin- And Beta-Arrestin Dependent And Its Plasma Membrane Insertion From The Recycling Endosomes Requires Phosphoinositide 3-Kinase (Pik3ca) And Scamp2 |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 5 antibodyAnti-Na(+/H(+ Exchanger 5 antibodyAnti-Nhe-5 antibodyAnti-Solute Carrier Family 9 Member 5 antibodyAnti-SLC9A5 antibodyAnti-NHE5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
