| Post Translational Modifications | Phosphorylated by PRKAA2.promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. |
| Protein Name | Sodium/Hydrogen Exchanger 5Na(+/H(+ Exchanger 5Nhe-5Solute Carrier Family 9 Member 5 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneCell ProjectionDendritic Spine MembraneSynaptic Cell MembraneCell JunctionFocal AdhesionCycles Between Recycling Endosome And Plasma Membrane In Response To Diverse StimuliIts Internalization Is Clathrin- And Beta-Arrestin Dependent And Its Plasma Membrane Insertion From The Recycling Endosomes Requires Phosphoinositide 3-Kinase (Pik3ca) And Scamp2 |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 5 antibodyAnti-Na(+/H(+ Exchanger 5 antibodyAnti-Nhe-5 antibodyAnti-Solute Carrier Family 9 Member 5 antibodyAnti-SLC9A5 antibodyAnti-NHE5 antibody |
Information sourced from Uniprot.org
