| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Mitochondrial sodium/calcium exchanger protein/K+/Ca2+-exchange protein 6 (494-543) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC8B1 |
| Gene ID: | 80024 |
| Uniprot ID: | NCLX_HUMAN |
| Immunogen Region: | 494-543 |
| Specificity: | NCKX6 Polyclonal Antibody detects endogenous levels of NCKX6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human SLC24A6. AA range:494-543 |
| Tissue Specificity | Present in pancreatic beta-cells (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-258 by PKA prevents calcium overload. |
| Function | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). |
| Protein Name | Mitochondrial Sodium/Calcium Exchanger Protein Na(+/K(+/Ca(2+-Exchange Protein 6 Sodium/Calcium Exchanger Protein - Mitochondrial Sodium/Potassium/Calcium Exchanger 6 Solute Carrier Family 24 Member 6 Solute Carrier Family 8 Member B1 |
| Database Links | Reactome: R-HSA-425561 Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Sodium/Calcium Exchanger Protein antibody Anti-Na(+/K(+/Ca(2+-Exchange Protein 6 antibody Anti-Sodium/Calcium Exchanger Protein - Mitochondrial antibody Anti-Sodium/Potassium/Calcium Exchanger 6 antibody Anti-Solute Carrier Family 24 Member 6 antibody Anti-Solute Carrier Family 8 Member B1 antibody Anti-SLC8B1 antibody Anti-NCKX6 antibody Anti-NCLX antibody Anti-SLC24A6 antibody |
Information sourced from Uniprot.org