Anti-SLC8B1 antibody (494-543) (STJ94360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SLC24A6. AA range:494-543
General Information
| Short Description | Rabbit polyclonal anti-Mitochondrial sodium/calcium exchanger protein/K+/Ca2+-exchange protein 6 (494-543) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC8B1 |
| Gene ID | 80024 |
| Uniprot ID | NCLX_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC24A6. AA range:494-543 |
| Immunogen Region | 494-543 |
| Specificity | NCKX6 Polyclonal Antibody detects endogenous levels of NCKX6 protein. |
Additional Info
| Tissue Specificity | Present in pancreatic beta-cells (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-258 by PKA prevents calcium overload. |
| Function | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). |
| Protein Name | Mitochondrial Sodium/Calcium Exchanger ProteinNa(+/K(+/Ca(2+-Exchange Protein 6Sodium/Calcium Exchanger Protein - MitochondrialSodium/Potassium/Calcium Exchanger 6Solute Carrier Family 24 Member 6Solute Carrier Family 8 Member B1 |
| Database Links | Reactome: R-HSA-425561Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Sodium/Calcium Exchanger Protein antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 6 antibodyAnti-Sodium/Calcium Exchanger Protein - Mitochondrial antibodyAnti-Sodium/Potassium/Calcium Exchanger 6 antibodyAnti-Solute Carrier Family 24 Member 6 antibodyAnti-Solute Carrier Family 8 Member B1 antibodyAnti-SLC8B1 antibodyAnti-NCKX6 antibodyAnti-NCLX antibodyAnti-SLC24A6 antibody |
Information sourced from Uniprot.org