• Western blot analysis of the lysates from HeLa cells using SLC24A6 antibody.
  • Western blot analysis of lysates from MCF-7 cells, using SLC24A6 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-SLC8B1 antibody (494-543) (STJ94360)

SKU:
STJ94360

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mitochondrial sodium/calcium exchanger protein/K+/Ca2+-exchange protein 6 (494-543) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC8B1
Gene ID: 80024
Uniprot ID: NCLX_HUMAN
Immunogen Region: 494-543
Specificity: NCKX6 Polyclonal Antibody detects endogenous levels of NCKX6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human SLC24A6. AA range:494-543
Tissue Specificity Present in pancreatic beta-cells (at protein level).
Post Translational Modifications Phosphorylation at Ser-258 by PKA prevents calcium overload.
Function Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
Protein Name Mitochondrial Sodium/Calcium Exchanger Protein
Na(+/K(+/Ca(2+-Exchange Protein 6
Sodium/Calcium Exchanger Protein - Mitochondrial
Sodium/Potassium/Calcium Exchanger 6
Solute Carrier Family 24 Member 6
Solute Carrier Family 8 Member B1
Database Links Reactome: R-HSA-425561
Reactome: R-HSA-8949215
Cellular Localisation Mitochondrion Inner Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Mitochondrial Sodium/Calcium Exchanger Protein antibody
Anti-Na(+/K(+/Ca(2+-Exchange Protein 6 antibody
Anti-Sodium/Calcium Exchanger Protein - Mitochondrial antibody
Anti-Sodium/Potassium/Calcium Exchanger 6 antibody
Anti-Solute Carrier Family 24 Member 6 antibody
Anti-Solute Carrier Family 8 Member B1 antibody
Anti-SLC8B1 antibody
Anti-NCKX6 antibody
Anti-NCLX antibody
Anti-SLC24A6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance