| Tissue Specificity | Present in pancreatic beta-cells (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-258 by PKA prevents calcium overload. |
| Function | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). |
| Protein Name | Mitochondrial Sodium/Calcium Exchanger ProteinNa(+/K(+/Ca(2+-Exchange Protein 6Sodium/Calcium Exchanger Protein - MitochondrialSodium/Potassium/Calcium Exchanger 6Solute Carrier Family 24 Member 6Solute Carrier Family 8 Member B1 |
| Database Links | Reactome: R-HSA-425561Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Sodium/Calcium Exchanger Protein antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 6 antibodyAnti-Sodium/Calcium Exchanger Protein - Mitochondrial antibodyAnti-Sodium/Potassium/Calcium Exchanger 6 antibodyAnti-Solute Carrier Family 24 Member 6 antibodyAnti-Solute Carrier Family 8 Member B1 antibodyAnti-SLC8B1 antibodyAnti-NCKX6 antibodyAnti-NCLX antibodyAnti-SLC24A6 antibody |
Information sourced from Uniprot.org
