| Tissue Specificity | Expressed in the brush border membrane in the kidney (at protein level). Kidney, small intestine, liver and placenta. |
| Function | Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules. |
| Protein Name | B(0 -+-Type Amino Acid Transporter 1B(0 -+At1Glycoprotein-Associated Amino Acid Transporter B0 -+At1Solute Carrier Family 7 Member 9 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230Reactome: R-HSA-5619113Reactome: R-HSA-5660883 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-B(0 -+-Type Amino Acid Transporter 1 antibodyAnti-B(0 -+At1 antibodyAnti-Glycoprotein-Associated Amino Acid Transporter B0 -+At1 antibodyAnti-Solute Carrier Family 7 Member 9 antibodyAnti-SLC7A9 antibodyAnti-BAT1 antibody |
Information sourced from Uniprot.org
