| Post Translational Modifications | Phosphorylated by PKC and dephosphorylated by PP1/PP2A. |
| Function | High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity. |
| Protein Name | High Affinity Choline Transporter 1Hemicholinium-3-Sensitive Choline TransporterChtSolute Carrier Family 5 Member 7 |
| Database Links | Reactome: R-MMU-264642Reactome: -MMU-425366 |
| Cellular Localisation | Presynaptic Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonEarly Endosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneLocalized To Motor Neuron Axons |
| Alternative Antibody Names | Anti-High Affinity Choline Transporter 1 antibodyAnti-Hemicholinium-3-Sensitive Choline Transporter antibodyAnti-Cht antibodyAnti-Solute Carrier Family 5 Member 7 antibodyAnti-Slc5a7 antibodyAnti-Cht1 antibody |
Information sourced from Uniprot.org
