| Function | Isoform 1: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney. Isoform 2: Appears to have no transporter activity. |
| Protein Name | Sodium/Mannose Cotransporter Slc5a10Sodium/Glucose Cotransporter 5Na(+/Glucose Cotransporter 5Solute Carrier Family 5 Member 10 |
| Database Links | Reactome: R-HSA-189200 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Mannose Cotransporter Slc5a10 antibodyAnti-Sodium/Glucose Cotransporter 5 antibodyAnti-Na(+/Glucose Cotransporter 5 antibodyAnti-Solute Carrier Family 5 Member 10 antibodyAnti-SLC5A10 antibodyAnti-SGLT5 antibody |
Information sourced from Uniprot.org
