| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC5A10 (ECD) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC5A10 |
| Gene ID: |
125206 |
| Uniprot ID: |
SC5AA_HUMAN |
| Immunogen Region: |
ECD |
| Specificity: |
Specific for SLC5A10. |
| Immunogen: |
A synthetic peptide from 1t extracellular domain of human SLC5A10 conjugated to blue carrier protein was used as the antigen. |
| Function | Isoform 1: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney. Isoform 2: Appears to have no transporter activity. |
| Protein Name | Sodium/Mannose Cotransporter Slc5a10Sodium/Glucose Cotransporter 5Na(+/Glucose Cotransporter 5Solute Carrier Family 5 Member 10 |
| Database Links | Reactome: R-HSA-189200 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Mannose Cotransporter Slc5a10 antibodyAnti-Sodium/Glucose Cotransporter 5 antibodyAnti-Na(+/Glucose Cotransporter 5 antibodyAnti-Solute Carrier Family 5 Member 10 antibodyAnti-SLC5A10 antibodyAnti-SGLT5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
