| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SLC4A8 (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments in Human Brain (Cerebellum) , Mouse Brain and Rat Brain lysates, and in lysates of Human Breast Cancer, Human Kidney and Human Lymph Node gave no specific signal |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SLC4A8 |
| Gene ID: | 9498 |
| Uniprot ID: | S4A8_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001035049.1; NP_004849.2 |
| Specificity: | This antibody is expected to recognize isoform a and b (NP_001035049.1; NP_004849.2). |
| Immunogen Sequence: | TNLEVKNGVNCEH |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. Mediates sodium reabsorption in the renal cortical collecting ducts. |
| Protein Name | Electroneutral Sodium Bicarbonate Exchanger 1Electroneutral Na(+-Driven Cl-Hco3 ExchangerSolute Carrier Family 4 Member 8K-Nbc3 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneIsoform 1: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneIsoform 5: Cell Membrane |
| Alternative Antibody Names | Anti-Electroneutral Sodium Bicarbonate Exchanger 1 antibodyAnti-Electroneutral Na(+-Driven Cl-Hco3 Exchanger antibodyAnti-Solute Carrier Family 4 Member 8 antibodyAnti-K-Nbc3 antibodyAnti-SLC4A8 antibodyAnti-KIAA0739 antibodyAnti-NBC antibodyAnti-NBC3 antibodyAnti-NDCBE1 antibody |
Information sourced from Uniprot.org