| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC4A8 |
| Gene ID: | 9498 |
| Uniprot ID: | S4A8_HUMAN |
| Immunogen Region: | 1-90 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC4A8 (NP_001035049.1). |
| Immunogen Sequence: | MPAAGSNEPDGVLSYQRPDE EAVVDQGGTSTILNIHYEKE ELEGHRTLYVGVRMPLGRQS HRHHRTHGQKHRRRGRGKGA SQGEEGLEAL |
| Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. Isoform 1: Expressed in the brain. Isoform 4: Expressed in the brain, heart and kidney. Isoform 5: Expressed in the brain, heart and kidney. |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. Mediates sodium reabsorption in the renal cortical collecting ducts. |
| Protein Name | Electroneutral Sodium Bicarbonate Exchanger 1 Electroneutral Na(+-Driven Cl-Hco3 Exchanger Solute Carrier Family 4 Member 8 K-Nbc3 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Isoform 1: Cell Membrane Isoform 3: Cell Membrane Isoform 4: Cell Membrane Isoform 5: Cell Membrane |
| Alternative Antibody Names | Anti-Electroneutral Sodium Bicarbonate Exchanger 1 antibody Anti-Electroneutral Na(+-Driven Cl-Hco3 Exchanger antibody Anti-Solute Carrier Family 4 Member 8 antibody Anti-K-Nbc3 antibody Anti-SLC4A8 antibody Anti-KIAA0739 antibody Anti-NBC antibody Anti-NBC3 antibody Anti-NDCBE1 antibody |
Information sourced from Uniprot.org