| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC4A8 (1-90) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A8 |
| Gene ID: |
9498 |
| Uniprot ID: |
S4A8_HUMAN |
| Immunogen Region: |
1-90 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC4A8 (NP_001035049.1). |
| Immunogen Sequence: |
MPAAGSNEPDGVLSYQRPDE EAVVDQGGTSTILNIHYEKE ELEGHRTLYVGVRMPLGRQS HRHHRTHGQKHRRRGRGKGA SQGEEGLEAL |
| Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. Isoform 1: Expressed in the brain. Isoform 4: Expressed in the brain, heart and kidney. Isoform 5: Expressed in the brain, heart and kidney. |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. Mediates sodium reabsorption in the renal cortical collecting ducts. |
| Protein Name | Electroneutral Sodium Bicarbonate Exchanger 1Electroneutral Na(+-Driven Cl-Hco3 ExchangerSolute Carrier Family 4 Member 8K-Nbc3 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneIsoform 1: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneIsoform 5: Cell Membrane |
| Alternative Antibody Names | Anti-Electroneutral Sodium Bicarbonate Exchanger 1 antibodyAnti-Electroneutral Na(+-Driven Cl-Hco3 Exchanger antibodyAnti-Solute Carrier Family 4 Member 8 antibodyAnti-K-Nbc3 antibodyAnti-SLC4A8 antibodyAnti-KIAA0739 antibodyAnti-NBC antibodyAnti-NBC3 antibodyAnti-NDCBE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
