| Short Description : | Rabbit polyclonal anti-Electroneutral sodium bicarbonate exchanger 1 and Sodium-driven chloride bicarbonate exchanger (411-460 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC4A8SLC4A10 |
| Gene ID: | 949857282 |
| Uniprot ID: | S4A8_HUMANS4A10_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SLC4A8/10 at the amino acid range 411-460 |
| Immunogen Region: | 411-460 aa |
| Specificity: | SLC4A8/10 Polyclonal Antibody detects endogenous levels of SLC4A8/10 protein. |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. |
| Protein Name | Electroneutral Sodium Bicarbonate Exchanger 1Electroneutral Na(+-Driven Cl-Hco3 ExchangerSolute Carrier Family 4 Member 8K-Nbc3 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Electroneutral Sodium Bicarbonate Exchanger 1 antibodyAnti-Electroneutral Na(+-Driven Cl-Hco3 Exchanger antibodyAnti-Solute Carrier Family 4 Member 8 antibodyAnti-K-Nbc3 antibodyAnti-SLC4A8 antibodyAnti-KIAA0739 antibodyAnti-NBC antibodyAnti-NBC3 antibodyAnti-NDCBE1 antibody |
Information sourced from Uniprot.org
