| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC4A7 |
| Gene ID: | 9497 |
| Uniprot ID: | S4A7_HUMAN |
| Immunogen Region: | 1151-1214 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1151-1214 of human SLC4A7 (NP_003606.3). |
| Immunogen Sequence: | KKEKEEAERMLQDDDDTVHL PFEGGSLLQIPVKALKYSPD KPVSVKISFEDEPRKKYVDA ETSL |
| Tissue Specificity | Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1: Expressed in skeletal muscle and heart muscle. |
| Function | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. Isoform 6: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. |
| Protein Name | Sodium Bicarbonate Cotransporter 3 Electroneutral Na/Hco(3 Cotransporter Sodium Bicarbonate Cotransporter 2 Sodium Bicarbonate Cotransporter 2b Bicarbonate Transporter Solute Carrier Family 4 Member 7 |
| Database Links | Reactome: R-HSA-425381 Reactome: R-HSA-9013405 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013409 Reactome: R-HSA-9035034 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Cell Projection Stereocilium Cell Membrane Localizes To The Stereocilia Of Cochlear Outer Hair Cells And To The Lateral Membrane Of Cochlear Inner Hair Cells Isoform 6: Cell Membrane |
| Alternative Antibody Names | Anti-Sodium Bicarbonate Cotransporter 3 antibody Anti-Electroneutral Na/Hco(3 Cotransporter antibody Anti-Sodium Bicarbonate Cotransporter 2 antibody Anti-Sodium Bicarbonate Cotransporter 2b antibody Anti-Bicarbonate Transporter antibody Anti-Solute Carrier Family 4 Member 7 antibody Anti-SLC4A7 antibody Anti-BT antibody Anti-NBC2 antibody Anti-NBC2B antibody Anti-NBC3 antibody Anti-NBCn1 antibody Anti-SBC2 antibody Anti-SLC4A6 antibody |
Information sourced from Uniprot.org