| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC4A7 (1151-1214) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A7 |
| Gene ID: |
9497 |
| Uniprot ID: |
S4A7_HUMAN |
| Immunogen Region: |
1151-1214 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1151-1214 of human SLC4A7 (NP_003606.3). |
| Immunogen Sequence: |
KKEKEEAERMLQDDDDTVHL PFEGGSLLQIPVKALKYSPD KPVSVKISFEDEPRKKYVDA ETSL |
| Tissue Specificity | Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1: Expressed in skeletal muscle and heart muscle. |
| Function | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. Isoform 6: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. |
| Protein Name | Sodium Bicarbonate Cotransporter 3Electroneutral Na/Hco(3 CotransporterSodium Bicarbonate Cotransporter 2Sodium Bicarbonate Cotransporter 2bBicarbonate TransporterSolute Carrier Family 4 Member 7 |
| Database Links | Reactome: R-HSA-425381Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9035034 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell ProjectionStereociliumCell MembraneLocalizes To The Stereocilia Of Cochlear Outer Hair Cells And To The Lateral Membrane Of Cochlear Inner Hair CellsIsoform 6: Cell Membrane |
| Alternative Antibody Names | Anti-Sodium Bicarbonate Cotransporter 3 antibodyAnti-Electroneutral Na/Hco(3 Cotransporter antibodyAnti-Sodium Bicarbonate Cotransporter 2 antibodyAnti-Sodium Bicarbonate Cotransporter 2b antibodyAnti-Bicarbonate Transporter antibodyAnti-Solute Carrier Family 4 Member 7 antibodyAnti-SLC4A7 antibodyAnti-BT antibodyAnti-NBC2 antibodyAnti-NBC2B antibodyAnti-NBC3 antibodyAnti-NBCn1 antibodyAnti-SBC2 antibodyAnti-SLC4A6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
