Anti-SLC4A4 antibody (STJA0006804)

SKU:
STJA0006804
£48.00 - £252.00
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Electrogenic sodium bicarbonate cotransporter 1/HCO3-cotransporter is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC4A4
Gene ID: 8671
Uniprot ID: S4A4_HUMAN
Specificity: This antibody detects endogenous levels of SLC4A4 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human SLC4A4
Post Translational Modifications Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase.phosphorylation seems to inhibit SLC4A4 activity. N-glycosylated. May not be necessary for the transporter basic functions.
Function Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Protein Name Electrogenic Sodium Bicarbonate Cotransporter 1
Sodium Bicarbonate Cotransporter
Na(+/Hco3(- Cotransporter
Solute Carrier Family 4 Member 4
Knbc1
Database Links Reactome: R-HSA-425381
Reactome: R-HSA-5619054
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Alternative Antibody Names Anti-Electrogenic Sodium Bicarbonate Cotransporter 1 antibody
Anti-Sodium Bicarbonate Cotransporter antibody
Anti-Na(+/Hco3(- Cotransporter antibody
Anti-Solute Carrier Family 4 Member 4 antibody
Anti-Knbc1 antibody
Anti-SLC4A4 antibody
Anti-NBC antibody
Anti-NBC1 antibody
Anti-NBCE1 antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ27285 Anti-SLC4A4 antibody (978-1078) (STJ27285) Rabbit Polyclonal Human/Mouse/Rat WB/IF/ICC/ELISA
STJ90000 Anti-ACR antibody (40-120 aa) (STJ90000) Rabbit Polyclonal Human/Rat/Mouse WB/IHC/IF/ELISA
STJ23044 Anti-CDH23 antibody (STJ23044) Rabbit Polyclonal Human/Mouse WB/IHC-P/ELISA
STJ27544 Anti-WNK3 antibody (STJ27544) Rabbit Polyclonal Human/Mouse/Rat WB/IHC-P/ELISA
STJ28585 Anti-PRDM14 antibody (STJ28585) Rabbit Polyclonal Human/Mouse/Rat WB/ELISA
!