| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Electrogenic sodium bicarbonate cotransporter 1/HCO3-cotransporter is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A4 |
| Gene ID: |
8671 |
| Uniprot ID: |
S4A4_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SLC4A4 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human SLC4A4 |
| Post Translational Modifications | Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase.phosphorylation seems to inhibit SLC4A4 activity. N-glycosylated. May not be necessary for the transporter basic functions. |
| Function | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. |
| Protein Name | Electrogenic Sodium Bicarbonate Cotransporter 1Sodium Bicarbonate CotransporterNa(+/Hco3(- CotransporterSolute Carrier Family 4 Member 4Knbc1 |
| Database Links | Reactome: R-HSA-425381Reactome: R-HSA-5619054 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Electrogenic Sodium Bicarbonate Cotransporter 1 antibodyAnti-Sodium Bicarbonate Cotransporter antibodyAnti-Na(+/Hco3(- Cotransporter antibodyAnti-Solute Carrier Family 4 Member 4 antibodyAnti-Knbc1 antibodyAnti-SLC4A4 antibodyAnti-NBC antibodyAnti-NBC1 antibodyAnti-NBCE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
