| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC47A2 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC47A2 |
| Gene ID: |
146802 |
| Uniprot ID: |
S47A2_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for SLC47A2. |
| Immunogen: |
A synthetic peptide from c-terminal region of human SLC47A2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. Isoform 6: Non-functional protein. |
| Protein Name | Multidrug And Toxin Extrusion Protein 2Mate-2Hmate-2Kidney-Specific H(+/Organic Cation AntiporterSolute Carrier Family 47 Member 2 |
| Database Links | Reactome: R-HSA-425366 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneDetected In The Renal Urinary TubulesIsoform 6: Apical Cell MembraneLocalized At The Brush Border Membranes Of The Proximal Tubules |
| Alternative Antibody Names | Anti-Multidrug And Toxin Extrusion Protein 2 antibodyAnti-Mate-2 antibodyAnti-Hmate-2 antibodyAnti-Kidney-Specific H(+/Organic Cation Antiporter antibodyAnti-Solute Carrier Family 47 Member 2 antibodyAnti-SLC47A2 antibodyAnti-MATE2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
