| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC39A7 (235-380) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC39A7 |
| Gene ID: |
7922 |
| Uniprot ID: |
S39A7_HUMAN |
| Immunogen Region: |
235-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 235-380 of human SLC39A7 (NP_008910.2). |
| Immunogen Sequence: |
KFVRHVKGGHGHSHGHGHAH SHTRGSHGHGRQERSTKEKQ SSEEEEKETRGVQKRRGGST VPKDGPVRPQNAEEEKRGLD LRVSGYLNLAADLAHNFTDG LAIGASFRGGRGLGILTTMT VLLHEVPHEVGDFAILVQSG CSKKQA |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. Methylation at some His residue by METTL9 leads to reduced zinc-binding. |
| Function | Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. Has a protective role against ER stress in different biological contexts. Mediates Zn(2+)-induced ferroptosis. |
| Protein Name | Zinc Transporter Slc39a7Histidine-Rich Membrane Protein Ke4Really Interesting New Gene 5 ProteinSolute Carrier Family 39 Member 7Zrt- - Irt-Like Protein 7Zip7 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi ApparatusCis-Golgi Network Membrane |
| Alternative Antibody Names | Anti-Zinc Transporter Slc39a7 antibodyAnti-Histidine-Rich Membrane Protein Ke4 antibodyAnti-Really Interesting New Gene 5 Protein antibodyAnti-Solute Carrier Family 39 Member 7 antibodyAnti-Zrt- - Irt-Like Protein 7 antibodyAnti-Zip7 antibodyAnti-SLC39A7 antibodyAnti-HKE4 antibodyAnti-RING5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
