| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC31A2 |
| Gene ID: | 1318 |
| Uniprot ID: | COPT2_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse Slc31a2 (NP_001277447.1). |
| Immunogen Sequence: | MHFIFSDEAVLLFDFWRVHS PTGMALSVLVVLLLAVLYEG IKVGKAKLLHKTLESLPATN SQQFILGPDQDSTGSRSTSD NRTRLRWFLCYFGQSLVHVI |
| Tissue Specificity | Ubiquitous with high expression in placenta and heart. |
| Post Translational Modifications | Ubiquitinated.ubiquitination and the subsequent proteasomal degradation are prevent by SLC31A1 that stabilizes it. |
| Function | Does not function as a copper(1+) importer in vivo. However, in vitro functions as a low-affinity copper(1+) importer. Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1. |
| Protein Name | Protein Slc31a2 Copper Transporter 2 Hctr2 Solute Carrier Family 31 Member 2 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Membrane Late Endosome Membrane Lysosome Membrane Plasma Membrane Localization Is Partial |
| Alternative Antibody Names | Anti-Protein Slc31a2 antibody Anti-Copper Transporter 2 antibody Anti-Hctr2 antibody Anti-Solute Carrier Family 31 Member 2 antibody Anti-SLC31A2 antibody Anti-COPT2 antibody Anti-CTR2 antibody |
Information sourced from Uniprot.org