Anti-SLC30A10 antibody (400-470 aa) (STJ13102227)

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STJ13102227-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC30A10 (400-470 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:3000 recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Slc30a10
Gene ID: 226781
Uniprot ID: ZNT10_MOUSE
Immunogen Region: 400-470 aa
Specificity: Specific for SLC30A10.
Immunogen: A synthetic peptide from aa region 400-470 of mouse SLC30A10 conjugated to blue carrier protein was used as the antigen.
Function Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes.
Protein Name Calcium/Manganese Antiporter Slc30a10
Solute Carrier Family 30 Member 10
Database Links Reactome: R-MMU-425410
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Recycling Endosome Membrane
Early Endosome Membrane
Localization To The Golgi And Plasma Membrane Is Regulated By Zinc
Alternative Antibody Names Anti-Calcium/Manganese Antiporter Slc30a10 antibody
Anti-Solute Carrier Family 30 Member 10 antibody
Anti-Slc30a10 antibody

Information sourced from Uniprot.org

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