| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Solute carrier family 2, facilitated glucose transporter member 1 (400-492 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-GLUT1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2ak |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC2A1 |
| Gene ID: | 6513 |
| Uniprot ID: | GTR1_HUMAN |
| Immunogen Region: | 400-492 aa |
| Specificity: | This antibody detects endogenous levels of human GLUT-1. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section. The antibody was |
| Immunogen: | Synthesized peptide derived from the human GLUT-1 at the amino acid range 400-492 |
| Post Translational Modifications | Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization. |
| Function | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity.can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation. |
| Protein Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1 Glucose Transporter Type 1 - Erythrocyte/Brain Glut-1 Hepg2 Glucose Transporter |
| Database Links | Reactome: R-HSA-189200 Reactome: R-HSA-196836 Reactome: R-HSA-422356 Reactome: R-HSA-5619043 Reactome: R-HSA-5653890 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Melanosome Photoreceptor Inner Segment Localizes Primarily At The Cell Surface Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1 antibody Anti-Glucose Transporter Type 1 - Erythrocyte/Brain antibody Anti-Glut-1 antibody Anti-Hepg2 Glucose Transporter antibody Anti-SLC2A1 antibody Anti-GLUT1 antibody |
Information sourced from Uniprot.org