Tissue Specificity | Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart. |
Function | Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Transports uridine. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. |
Protein Name | Solute Carrier Family 28 Member 3Concentrative Na(+-Nucleoside Cotransporter 3Cnt 3Hcnt3 |
Database Links | Reactome: R-HSA-83936Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Endoplasmic Reticulum Membrane |
Alternative Antibody Names | Anti-Solute Carrier Family 28 Member 3 antibodyAnti-Concentrative Na(+-Nucleoside Cotransporter 3 antibodyAnti-Cnt 3 antibodyAnti-Hcnt3 antibodyAnti-SLC28A3 antibodyAnti-CNT3 antibody |
Information sourced from Uniprot.org