| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC26A3 (650-700) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 Mu g/Mu l |
| Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:100 ICC: 1:50-1:100 IF: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SLC26A3 |
| Gene ID: | 1811 |
| Uniprot ID: | S26A3_HUMAN |
| Immunogen Region: | 650-700 |
| Immunogen: | Synthetic peptide corresponding to amino acids within region 650-700 on human SCL26A3 protein. |
| Tissue Specificity | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. |
| Post Translational Modifications | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Protein Name | Chloride Anion Exchanger Down-Regulated In Adenoma Protein Dra Solute Carrier Family 26 Member 3 |
| Database Links | Reactome: R-HSA-427601 Reactome: R-HSA-5619085 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Membrane Cell Membrane Localized In Sperm Membranes Midpiece Of Sperm Tail Colocalizes With Cftr At The Midpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Chloride Anion Exchanger antibody Anti-Down-Regulated In Adenoma antibody Anti-Protein Dra antibody Anti-Solute Carrier Family 26 Member 3 antibody Anti-SLC26A3 antibody Anti-DRA antibody |
Information sourced from Uniprot.org