| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC26A2 (540-739) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC26A2 |
| Gene ID: |
1836 |
| Uniprot ID: |
S26A2_HUMAN |
| Immunogen Region: |
540-739 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 540-739 of human SLC26A2 (NP_000103.2). |
| Immunogen Sequence: |
FCVILRTQKPKSSLLGLVEE SEVFESVSAYKNLQIKPGIK IFRFVAPLYYINKECFKSAL YKQTVNPILIKVAWKKAAKR KIKEKVVTLGGIQDEMSVQL SHDPLELHTIVIDCSAIQFL DTAGIHTLKEVRRDYEAIGI QVLLAQCNPTVRDSLTNGEY CKKEEENLLFYSVYEAMAFA EVSKNQKGVCVPNGLSLSSD |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | N-glycosylated. |
| Function | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions. Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. |
| Protein Name | Sulfate TransporterDiastrophic Dysplasia ProteinSolute Carrier Family 26 Member 2 |
| Database Links | Reactome: R-HSA-174362Reactome: R-HSA-3560792Reactome: R-HSA-427601 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Sulfate Transporter antibodyAnti-Diastrophic Dysplasia Protein antibodyAnti-Solute Carrier Family 26 Member 2 antibodyAnti-SLC26A2 antibodyAnti-DTD antibodyAnti-DTDST antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
