Anti-SLC26A2 antibody (540-739) (STJ28452)

SKU:
STJ28452

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Host: Rabbit
Applications: IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC26A2 (540-739) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC26A2
Gene ID: 1836
Uniprot ID: S26A2_HUMAN
Immunogen Region: 540-739
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 540-739 of human SLC26A2 (NP_000103.2).
Immunogen Sequence: FCVILRTQKPKSSLLGLVEE SEVFESVSAYKNLQIKPGIK IFRFVAPLYYINKECFKSAL YKQTVNPILIKVAWKKAAKR KIKEKVVTLGGIQDEMSVQL SHDPLELHTIVIDCSAIQFL DTAGIHTLKEVRRDYEAIGI QVLLAQCNPTVRDSLTNGEY CKKEEENLLFYSVYEAMAFA EVSKNQKGVCVPNGLSLSSD
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications N-glycosylated.
Function Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions. Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.
Protein Name Sulfate Transporter
Diastrophic Dysplasia Protein
Solute Carrier Family 26 Member 2
Database Links Reactome: R-HSA-174362
Reactome: R-HSA-3560792
Reactome: R-HSA-427601
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Alternative Antibody Names Anti-Sulfate Transporter antibody
Anti-Diastrophic Dysplasia Protein antibody
Anti-Solute Carrier Family 26 Member 2 antibody
Anti-SLC26A2 antibody
Anti-DTD antibody
Anti-DTDST antibody

Information sourced from Uniprot.org

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