| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC17A5 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC17A5 |
| Gene ID: |
26503 |
| Uniprot ID: |
S17A5_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC17A5 (NP_036566.1). |
| Immunogen Sequence: |
MRSPVRDLARNDGEESTDRT PLLPGAPRAEAAPVCCSARY NLAILAFFGFFIVYALRVNL SVALVDMVDSNTTLEDNRTS KACPEHSAPIKVHHNQTGKK |
| Tissue Specificity | In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. Highly expressed in salivary glands and liver, with lower levels of expression in brain, spleen kidney, muscle and pancreas. Expressed in acinar cells of salivary glands (at protein level). |
| Function | Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva. Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release. Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. |
| Protein Name | SialinH(+/Nitrate CotransporterH(+/Sialic Acid CotransporterAstMembrane Glycoprotein Hp59Solute Carrier Family 17 Member 5Vesicular Excitatory Amino Acid TransporterVeat |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-428643Reactome: R-HSA-5619035 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneLysosome Membrane |
| Alternative Antibody Names | Anti-Sialin antibodyAnti-H(+/Nitrate Cotransporter antibodyAnti-H(+/Sialic Acid Cotransporter antibodyAnti-Ast antibodyAnti-Membrane Glycoprotein Hp59 antibodyAnti-Solute Carrier Family 17 Member 5 antibodyAnti-Vesicular Excitatory Amino Acid Transporter antibodyAnti-Veat antibodyAnti-SLC17A5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
