| Tissue Specificity | Highly expressed in liver and heart. In adult brain tissue expression is largely confined to endothelial cells of the blood-brain barrier (at protein level). |
| Function | Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable). |
| Protein Name | Monocarboxylate Transporter 8Mct 8Monocarboxylate Transporter 7Mct 7Solute Carrier Family 16 Member 2X-Linked Pest-Containing Transporter |
| Database Links | Reactome: R-HSA-879518 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Monocarboxylate Transporter 8 antibodyAnti-Mct 8 antibodyAnti-Monocarboxylate Transporter 7 antibodyAnti-Mct 7 antibodyAnti-Solute Carrier Family 16 Member 2 antibodyAnti-X-Linked Pest-Containing Transporter antibodyAnti-SLC16A2 antibodyAnti-MCT7 antibodyAnti-MCT8 antibodyAnti-XPCT antibody |
Information sourced from Uniprot.org
