| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC14A1 |
| Gene ID: | 6563 |
| Uniprot ID: | UT1_HUMAN |
| Immunogen Region: | 244-257 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 158-257 of human SLC14A1 (NP_001295208.1). |
| Immunogen Sequence: | PIFSSALNSMLSKWDLPVFT LPFNMALSMYLSATGHYNPF FPAKLVIPITTAPNISWSDL SALELLKSIPVGVGQIYGCD NPWTGGIFLGAILLSSPLMC LHAAIGSLLGIAAGLSLSAP FEDIYFGLWGFNSSLACIAM GGMFMALTWQTHLLALGCAL FTAYLGVGMANFMAEVGLPA CTWPFCLATLLFLIMTTKNS NIYKMPLSKVTYPEENRIFY LQAKKRMVESPL |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in spleen erythroblasts and tumoral kidney. |
| Function | Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes. |
| Protein Name | Urea Transporter 1Solute Carrier Family 14 Member 1Urea Transporter - Erythrocyte |
| Database Links | Reactome: R-HSA-425366 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneRestricted To The Basolateral Membrane In Various Portions Of The Urothelium |
| Alternative Antibody Names | Anti-Urea Transporter 1 antibodyAnti-Solute Carrier Family 14 Member 1 antibodyAnti-Urea Transporter - Erythrocyte antibodyAnti-SLC14A1 antibodyAnti-HUT11 antibodyAnti-JK antibodyAnti-RACH1 antibodyAnti-UT1 antibodyAnti-UTE antibody |
Information sourced from Uniprot.org