| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC12A7 (940-990 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SLC12A7 |
| Gene ID: | 10723 |
| Uniprot ID: | S12A7_HUMAN |
| Immunogen Region: | 940-990 aa |
| Specificity: | Specific for SLC12A7. |
| Immunogen: | A synthetic peptide from aa region 940-990 of human SLC12A7 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. |
| Protein Name | Solute Carrier Family 12 Member 7Electroneutral Potassium-Chloride Cotransporter 4K-Cl Cotransporter 4 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 7 antibodyAnti-Electroneutral Potassium-Chloride Cotransporter 4 antibodyAnti-K-Cl Cotransporter 4 antibodyAnti-SLC12A7 antibodyAnti-KCC4 antibody |
Information sourced from Uniprot.org