| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC12A4 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SLC12A4 |
| Gene ID: | 6560 |
| Uniprot ID: | S12A4_HUMAN |
| Immunogen Region: | 2-50 aa |
| Specificity: | Specific for SLC12A4. |
| Immunogen: | A synthetic peptide from aa region 2-50 of human SLC12A4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Post Translational Modifications | Phosphorylated, phosphorylation may regulate transporter activity. |
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4: No transporter activity. |
| Protein Name | Solute Carrier Family 12 Member 4Electroneutral Potassium-Chloride Cotransporter 1Erythroid K-Cl Cotransporter 1Hkcc1 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 4 antibodyAnti-Electroneutral Potassium-Chloride Cotransporter 1 antibodyAnti-Erythroid K-Cl Cotransporter 1 antibodyAnti-Hkcc1 antibodyAnti-SLC12A4 antibodyAnti-KCC1 antibody |
Information sourced from Uniprot.org