| Tissue Specificity | Expressed predominantly in kidney, including in distal tubules (at protein level). Detected at low levels in heart, lung and liver. Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions. In atherosclerotic lesions, expressed in macrophages, smooth muscle cells and endothelial cells (at protein level). |
| Post Translational Modifications | Ubiquitinated.ubiquitination is essential for regulation of endocytosis. Phosphorylated at Thr-53, Thr-58 and Ser-71 by OXSR1/OSR1 and STK39/SPAK downstream of WNK4, promoting its activity. Phosphorylated in response to IL18. |
| Function | Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1. |
| Protein Name | Solute Carrier Family 12 Member 3Na-Cl SymporterThiazide-Sensitive Sodium-Chloride Cotransporter |
| Database Links | Reactome: R-MMU-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 3 antibodyAnti-Na-Cl Symporter antibodyAnti-Thiazide-Sensitive Sodium-Chloride Cotransporter antibodyAnti-Slc12a3 antibodyAnti-Ncc antibodyAnti-Tsc antibody |
Information sourced from Uniprot.org
