| Function | Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). |
| Protein Name | Superkiller Complex Protein 3Ski3Tetratricopeptide Repeat Protein 37Tpr Repeat Protein 37Tricho-Hepatic-Enteric Syndrome ProteinThespin |
| Database Links | Reactome: R-HSA-429958 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Superkiller Complex Protein 3 antibodyAnti-Ski3 antibodyAnti-Tetratricopeptide Repeat Protein 37 antibodyAnti-Tpr Repeat Protein 37 antibodyAnti-Tricho-Hepatic-Enteric Syndrome Protein antibodyAnti-Thespin antibodyAnti-SKIC3 antibodyAnti-KIAA0372 antibodyAnti-TTC37 antibody |
Information sourced from Uniprot.org
