| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SKI |
| Gene ID: | 6497 |
| Uniprot ID: | SKI_HUMAN |
| Immunogen Region: | 700-800 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 650-728 of human SKI (NP_003027.1). |
| Immunogen Sequence: | CDKGCEAGRLRAKYSAQIED LQVKLQHAEADREQLRADLL REREAREHLEKVVKELQEQL WPRARPEAAGSEGAAELEP |
| Post Translational Modifications | Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling. |
| Function | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. |
| Protein Name | Ski OncogeneProto-Oncogene C-Ski |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173795 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ski Oncogene antibodyAnti-Proto-Oncogene C-Ski antibodyAnti-SKI antibody |
Information sourced from Uniprot.org