| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Src kinase-associated phosphoprotein 1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SKAP1 |
| Gene ID: |
8631 |
| Uniprot ID: |
SKAP1_HUMAN |
| Specificity: |
SKAP1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable). |
| Function | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Src Kinase-Associated Phosphoprotein 1Src Family-Associated Phosphoprotein 1Src Kinase-Associated Phosphoprotein Of 55 KdaSkap-55Pp55 |
| Cellular Localisation | CytoplasmNucleusCell MembraneUpon T-Cell StimulationTranslocates To Lipid Rafts At The Cell Membrane |
| Alternative Antibody Names | Anti-Src Kinase-Associated Phosphoprotein 1 antibodyAnti-Src Family-Associated Phosphoprotein 1 antibodyAnti-Src Kinase-Associated Phosphoprotein Of 55 Kda antibodyAnti-Skap-55 antibodyAnti-Pp55 antibodyAnti-SKAP1 antibodyAnti-SCAP1 antibodyAnti-SKAP55 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
