| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SKAP1 (1-358) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SKAP1 |
| Gene ID: |
8631 |
| Uniprot ID: |
SKAP1_HUMAN |
| Immunogen Region: |
1-358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-358 of human SKAP1 (NP_001068567.1). |
| Immunogen Sequence: |
MQAAALPEEIRWLLEDAEEF LAEGLRNENLSAVARDHRDH ILRGFQQIKARYYWDFQPQG GDIGQDSSDDNHSGTLGLSL TSDAPFLSDYQDEGMEDIVK GAQELDNVIKQGYLEKKSKD HSFFGSEWQKRWCVVSRGLF YYYANEKSKQPKGTFLIKGY GVRMAPHLRRDSKKESCFEL TSQDRRSYEFTATSPAEARD WVDQISFLLKDLSSLTIPYE EDEEEEEKEETYDDIDGFD |
| Tissue Specificity | Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable). |
| Function | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Src Kinase-Associated Phosphoprotein 1Src Family-Associated Phosphoprotein 1Src Kinase-Associated Phosphoprotein Of 55 KdaSkap-55Pp55 |
| Cellular Localisation | CytoplasmNucleusCell MembraneUpon T-Cell StimulationTranslocates To Lipid Rafts At The Cell Membrane |
| Alternative Antibody Names | Anti-Src Kinase-Associated Phosphoprotein 1 antibodyAnti-Src Family-Associated Phosphoprotein 1 antibodyAnti-Src Kinase-Associated Phosphoprotein Of 55 Kda antibodyAnti-Skap-55 antibodyAnti-Pp55 antibodyAnti-SKAP1 antibodyAnti-SCAP1 antibodyAnti-SKAP55 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
