| Tissue Specificity | Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable). |
| Function | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Src Kinase-Associated Phosphoprotein 1Src Family-Associated Phosphoprotein 1Src Kinase-Associated Phosphoprotein Of 55 KdaSkap-55Pp55 |
| Cellular Localisation | CytoplasmNucleusCell MembraneUpon T-Cell StimulationTranslocates To Lipid Rafts At The Cell Membrane |
| Alternative Antibody Names | Anti-Src Kinase-Associated Phosphoprotein 1 antibodyAnti-Src Family-Associated Phosphoprotein 1 antibodyAnti-Src Kinase-Associated Phosphoprotein Of 55 Kda antibodyAnti-Skap-55 antibodyAnti-Pp55 antibodyAnti-SKAP1 antibodyAnti-SCAP1 antibodyAnti-SKAP55 antibody |
Information sourced from Uniprot.org
