| Tissue Specificity | Widely expressed. |
| Function | NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| Protein Name | Nad-Dependent Protein Deacylase Sirtuin-5 - MitochondrialRegulatory Protein Sir2 Homolog 5Sir2-Like Protein 5 |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion MatrixMitochondrion Intermembrane SpaceCytoplasmCytosolNucleusMainly MitochondrialAlso Present ExtramitochondriallyWith A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The NucleusIsoform 1: CytoplasmMitochondrionIsoform 2: Mitochondrion |
| Alternative Antibody Names | Anti-Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial antibodyAnti-Regulatory Protein Sir2 Homolog 5 antibodyAnti-Sir2-Like Protein 5 antibodyAnti-SIRT5 antibodyAnti-SIR2L5 antibody |
Information sourced from Uniprot.org
![Western blot analysis of various lysates, using [KO Validated] SIRT5 rabbit polyclonal antibody (STJ28350) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101643/389632/STJ28350_WB_2__71470.1713159351.jpg?c=1 "Western blot analysis of various lysates, using [KO Validated] SIRT5 rabbit polyclonal antibody (STJ28350) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
