| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIPA1 |
| Gene ID: | 6494 |
| Uniprot ID: | SIPA1_HUMAN |
| Immunogen Region: | 763-1042 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 763-1042 of human SIPA1 (NP_694985.29). |
| Immunogen Sequence: | ESGRPRRSFSELYTLSLQEP SRRGAPDPVQDEVQGVTLLP TTKQLLHLCLQDGGSPPGPG DLAEERTEFLHSQNSLSPRS SLSDEAPVLPNTTPDLLLAT TAKPSVPSADSETPLTQDRP GSPSGSEDKGNPAPELRASF LPRTLSLRNSISRIMSEAGS GTLEDEWQAISEIASTCNTI LESLSREGQPIPESGDPKGT PKSDAEPEPGNLSEKVSHLE SMLRKLQEDLQKEKADRAA |
| Tissue Specificity | Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. |
| Function | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. |
| Protein Name | Signal-Induced Proliferation-Associated Protein 1Sipa-1Gtpase-Activating Protein Spa-1P130 Spa-1 |
| Database Links | Reactome: R-HSA-392517 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionEndomembrane SystemPeripheral Membrane ProteinMostly Localized In The Perinuclear Membraneous Region |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated Protein 1 antibodyAnti-Sipa-1 antibodyAnti-Gtpase-Activating Protein Spa-1 antibodyAnti-P130 Spa-1 antibodyAnti-SIPA1 antibodyAnti-SPA1 antibody |
Information sourced from Uniprot.org