Anti-SIPA1 antibody (763-1042) (STJ114143)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SIPA1 (763-1042) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIPA1 |
| Gene ID | 6494 |
| Uniprot ID | SIPA1_HUMAN |
| Immunogen Region | 763-1042 |
| Immunogen Sequence | ESGRPRRSFSELYTLSLQEP SRRGAPDPVQDEVQGVTLLP TTKQLLHLCLQDGGSPPGPG DLAEERTEFLHSQNSLSPRS SLSDEAPVLPNTTPDLLLAT TAKPSVPSADSETPLTQDRP GSPSGSEDKGNPAPELRASF LPRTLSLRNSISRIMSEAGS GTLEDEWQAISEIASTCNTI LESLSREGQPIPESGDPKGT PKSDAEPEPGNLSEKVSHLE SMLRKLQEDLQKEKADRAA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 763-1042 of human SIPA1 (NP_694985.29). |
Additional Info
| Tissue Specificity | Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. |
| Function | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. |
| Protein Name | Signal-Induced Proliferation-Associated Protein 1Sipa-1Gtpase-Activating Protein Spa-1P130 Spa-1 |
| Database Links | Reactome: R-HSA-392517 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionEndomembrane SystemPeripheral Membrane ProteinMostly Localized In The Perinuclear Membraneous Region |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated Protein 1 antibodyAnti-Sipa-1 antibodyAnti-Gtpase-Activating Protein Spa-1 antibodyAnti-P130 Spa-1 antibodyAnti-SIPA1 antibodyAnti-SPA1 antibody |
Information sourced from Uniprot.org