| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Paired amphipathic helix protein Sin3b (221-270 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIN3B |
| Gene ID: |
23309 |
| Uniprot ID: |
SIN3B_HUMAN |
| Immunogen Region: |
221-270 aa |
| Specificity: |
Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human SIN3B at the amino acid range 221-270 |
| Function | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. |
| Protein Name | Paired Amphipathic Helix Protein Sin3bHistone Deacetylase Complex Subunit Sin3bTranscriptional Corepressor Sin3b |
| Database Links | Reactome: R-HSA-400206 O75182-1Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9707564 O75182-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3b antibodyAnti-Histone Deacetylase Complex Subunit Sin3b antibodyAnti-Transcriptional Corepressor Sin3b antibodyAnti-SIN3B antibodyAnti-KIAA0700 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
