| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SHANK3 (1-150) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SHANK3Uniprot ID=SHAN3_HUMAN" |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SHANK3 (NP_277052.1). |
| Immunogen Sequence: |
MDGPGASAVVVRVGIPDLQQ TKCLRLDPAAPVWAAKQRVL CALNHSLQDALNYGLFQPPS RGRAGKFLDEERLLQEYPPN LDTPLPYLEFRYKRRVYAQN LIDDKQFAKLHTKANLKKFM DYVQLHSTDKVARLLDKGLD PNFHDPDSGE |
| Tissue Specificity | Expressed in the cerebral cortex and the cerebellum. |
| Function | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 3Shank3Proline-Rich Synapse-Associated Protein 2Prosap2 |
| Cellular Localisation | CytoplasmPostsynaptic DensityCell ProjectionDendritic SpineIn Neuronal CellsExtends Into The Region Subjacent To The Postsynaptic Density (Psd) |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 3 antibodyAnti-Shank3 antibodyAnti-Proline-Rich Synapse-Associated Protein 2 antibodyAnti-Prosap2 antibodyAnti-SHANK3 antibodyAnti-KIAA1650 antibodyAnti-PROSAP2 antibodyAnti-PSAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
