| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SFXN1 |
| Gene ID: | 94081 |
| Uniprot ID: | SFXN1_HUMAN |
| Immunogen Region: | 87-322 |
| Immunogen Sequence: | MILIGRMSAQVPMNMTITGC MMTFYRTTPAVLFWQWINQS FNAVVNYTNRSGDAPLTVNE LGTAYVSATTGAVATALGLN ALTKHVSPLIGRFVPFAAVA AANCINIPLMRQRELKVGIP VTDENGNRLGESANAAKQAI TQVVVSRILMAAPGMAIPPF IMNTLEKKAFLKRFPWMSAP IQVGLVGFCLVFATPLCCAL FPQKSSMSVTSLEAELQAKI QESHPELRRVYFNKGL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 87-322 of human SFXN1 (NP_073591.2). |
| Tissue Specificity | Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney. |
| Function | Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine. |
| Protein Name | Sideroflexin-1 |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sideroflexin-1 antibodyAnti-SFXN1 antibody |
Information sourced from Uniprot.org
