||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-SCP2 (1-322) is suitable for use in Western Blot and Immunohistochemistry.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SCP2 (NP_001007099.1).
| Tissue Specificity || Liver, fibroblasts, and placenta. |
| Post Translational Modifications || Isoform SCP2: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes. |
| Function || Isoform SCPx: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs. Isoform SCP2: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs. |
| Protein Name || Sterol Carrier Protein 2Scp-2Acetyl-Coa C-MyristoyltransferaseNon-Specific Lipid-Transfer ProteinNsl-TpPropanoyl-Coa C-AcyltransferaseScp-2/3-Oxoacyl-Coa ThiolaseScp-2/ThiolaseScp-ChiScpxSterol Carrier Protein XScp-XStraight-Chain Acyl-Coa OxidaseScox |
| Database Links || Reactome: R-HSA-193368 P22307-1Reactome: R-HSA-2046106Reactome: R-HSA-389887 P22307-1Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation || Isoform Scp2: PeroxisomeCytoplasmMitochondrionEndoplasmic ReticulumIsoform Scpx: Peroxisome |
| Alternative Antibody Names || Anti-Sterol Carrier Protein 2 antibodyAnti-Scp-2 antibodyAnti-Acetyl-Coa C-Myristoyltransferase antibodyAnti-Non-Specific Lipid-Transfer Protein antibodyAnti-Nsl-Tp antibodyAnti-Propanoyl-Coa C-Acyltransferase antibodyAnti-Scp-2/3-Oxoacyl-Coa Thiolase antibodyAnti-Scp-2/Thiolase antibodyAnti-Scp-Chi antibodyAnti-Scpx antibodyAnti-Sterol Carrier Protein X antibodyAnti-Scp-X antibodyAnti-Straight-Chain Acyl-Coa Oxidase antibodyAnti-Scox antibodyAnti-SCP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance