| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. |
| Protein Name | Splicing Factor 3b Subunit 2Pre-Mrna-Splicing Factor Sf3b 145 Kda SubunitSf3b145Spliceosome-Associated Protein 145Sap 145 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Splicing Factor 3b Subunit 2 antibodyAnti-Pre-Mrna-Splicing Factor Sf3b 145 Kda Subunit antibodyAnti-Sf3b145 antibodyAnti-Spliceosome-Associated Protein 145 antibodyAnti-Sap 145 antibodyAnti-SF3B2 antibodyAnti-SAP145 antibody |
Information sourced from Uniprot.org
