| Tissue Specificity | Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. |
| Post Translational Modifications | Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. |
| Function | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. |
| Protein Name | Serpine1 Mrna-Binding Protein 1Pai1 Rna-Binding Protein 1Pai-Rbp1Plasminogen Activator Inhibitor 1 Rna-Binding Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPerinuclear Region |
| Alternative Antibody Names | Anti-Serpine1 Mrna-Binding Protein 1 antibodyAnti-Pai1 Rna-Binding Protein 1 antibodyAnti-Pai-Rbp1 antibodyAnti-Plasminogen Activator Inhibitor 1 Rna-Binding Protein antibodyAnti-SERBP1 antibodyAnti-PAIRBP1 antibodyAnti-CGI-55 antibody |
Information sourced from Uniprot.org
