Anti-SENP2 antibody (366-589) (STJ119967)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SENP2 (366-589) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SENP2 |
| Gene ID | 59343 |
| Uniprot ID | SENP2_HUMAN |
| Immunogen Region | 366-589 |
| Immunogen Sequence | LELTEDMEKEISNALGHGPQ DEILSSAFKLRITRGDIQTL KNYHWLNDEVINFYMNLLVE RNKKQGYPALHVFSTFFYPK LKSGGYQAVKRWTKGVNLFE QEIILVPIHRKVHWSLVVID LRKKCLKYLDSMGQKGHRIC EILLQYLQDESKTKRNSDLN LLEWTHHSMKPHEIPQQLNG SDCGMFTCKYADYISRDKPI TFTQHQMPLFRKKMVWEILH QQLL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 366-589 of human SENP2 (NP_067640.2). |
Additional Info
| Post Translational Modifications | Polyubiquitinated.which leads to proteasomal degradation. |
| Function | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection. |
| Protein Name | Sentrin-Specific Protease 2Axam2Smt3-Specific Isopeptidase 2Smt3ip2Sentrin/Sumo-Specific Protease Senp2 |
| Database Links | Reactome: R-HSA-3065679 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinNucleoplasmic SideCytoplasmShuttles Between Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 2 antibodyAnti-Axam2 antibodyAnti-Smt3-Specific Isopeptidase 2 antibodyAnti-Smt3ip2 antibodyAnti-Sentrin/Sumo-Specific Protease Senp2 antibodyAnti-SENP2 antibodyAnti-KIAA1331 antibody |
Information sourced from Uniprot.org