| Tissue Specificity | Widely expressed, with high levels in the liver. |
| Function | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. |
| Protein Name | Translocation Protein Sec63 HomologDnaj Homolog Subfamily C Member 23 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Translocation Protein Sec63 Homolog antibodyAnti-Dnaj Homolog Subfamily C Member 23 antibodyAnti-SEC63 antibodyAnti-DNAJC23 antibodyAnti-SEC63L antibody |
Information sourced from Uniprot.org
