| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC61A2 |
| Gene ID: | 55176 |
| Uniprot ID: | S61A2_HUMAN |
| Immunogen Region: | 350-450 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human Sec61A (Q9H9S3). |
| Immunogen Sequence: | SMGAIFEDPVHVVVYIIFML GSCAFFSKTWIEVSGSSAKD VAKQLKEQQMVMRGHRDTSM VHELNRYIPTAAAFGGLCIG ALSVLADFLGAIGSGTGILL A |
| Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. |
| Protein Name | Protein Transport Protein Sec61 Subunit Alpha Isoform 2Sec61 Alpha-2 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1799339 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Transport Protein Sec61 Subunit Alpha Isoform 2 antibodyAnti-Sec61 Alpha-2 antibodyAnti-SEC61A2 antibody |
Information sourced from Uniprot.org