Anti-SEC11A antibody (37-145) (STJ112570)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SEC11A (37-145) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SEC11A |
| Gene ID | 23478 |
| Uniprot ID | SC11A_HUMAN |
| Immunogen Region | 37-145 |
| Immunogen Sequence | KGLMVITGSESPIVVVLSGS MEPAFHRGDLLFLTNRVEDP IRVGEIVVFRIEGREIPIVH RVLKIHEKQNGHIKFLTKGD NNAVDDRGLYKQGQHWLEKK DVVGRARGF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 37-145 of human SEC11A (NP_055115.1). |
Additional Info
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. |
| Protein Name | Signal Peptidase Complex Catalytic Subunit Sec11aEndopeptidase Sp18Microsomal Signal Peptidase 18 Kda SubunitSpase 18 Kda SubunitSec11 Homolog ASec11-Like Protein 1Spc18 |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085Reactome: R-HSA-9828806 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Signal Peptidase Complex Catalytic Subunit Sec11a antibodyAnti-Endopeptidase Sp18 antibodyAnti-Microsomal Signal Peptidase 18 Kda Subunit antibodyAnti-Spase 18 Kda Subunit antibodyAnti-Sec11 Homolog A antibodyAnti-Sec11-Like Protein 1 antibodyAnti-Spc18 antibodyAnti-SEC11A antibodyAnti-SEC11L1 antibodyAnti-SPC18 antibodyAnti-SPCS4A antibody |
Information sourced from Uniprot.org