| Host: | Rabbit |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-SDHB is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ZR339 |
| Conjugation: | Unconjugated |
| Isotype: | Rabbit IgG |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | SDHB |
| Gene ID: | 6390 |
| Uniprot ID: | SDHB_HUMAN |
| Specificity: | Positive control: GIST |
| Immunogen: | Synthetic peptide corresponding to residues in human SDHB was used as an immunogen |
| Function | Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - Mitochondrial Iron-Sulfur Subunit Of Complex Ii Ip Malate Dehydrogenase Quinone Iron-Sulfur Subunit |
| Database Links | Reactome: R-HSA-611105 Reactome: R-HSA-71403 Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner Membrane Peripheral Membrane Protein Matrix Side |
| Alternative Antibody Names | Anti-Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - Mitochondrial antibody Anti-Iron-Sulfur Subunit Of Complex Ii antibody Anti-Ip antibody Anti-Malate Dehydrogenase Quinone Iron-Sulfur Subunit antibody Anti-SDHB antibody Anti-SDH antibody Anti-SDH1 antibody |
Information sourced from Uniprot.org