| Short Description : | Rabbit polyclonal anti-Succinate dehydrogenase flavoprotein subunit, mitochondrial (551-600 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SDHA |
| Gene ID: | 6389 |
| Uniprot ID: | SDHA_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SDHA at the amino acid range 551-600 |
| Immunogen Region: | 551-600 aa |
| Specificity: | SDHA Polyclonal Antibody detects endogenous levels of SDHA protein. |
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - MitochondrialFlavoprotein Subunit Of Complex IiFpMalate Dehydrogenase Quinone Flavoprotein Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - Mitochondrial antibodyAnti-Flavoprotein Subunit Of Complex Ii antibodyAnti-Fp antibodyAnti-Malate Dehydrogenase Quinone Flavoprotein Subunit antibodyAnti-SDHA antibodyAnti-SDH2 antibodyAnti-SDHF antibody |
Information sourced from Uniprot.org
