| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. ENaC is activated through the proteolytic maturation of its subunits. Furin cleaves the SCNN1G subunit first, followed by cleavage by prostasin (PRSS8), which results in a stepwise increase in the open probability of the channel due to the release of an inhibitory tract. BPIFA1, which is recruited by the SCNN1B subunit, prevents the proteolytic activation of ENaC. N-glycosylated. N-linked glycans are processed to complex type during ENaC complex assembly and transport to the plasma membrane. |
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. |
| Protein Name | Epithelial Sodium Channel Subunit GammaEpithelial Na(+ Channel Subunit GammaGamma-EnacAmiloride-Sensitive Sodium Channel Subunit GammaGamma-NachNonvoltage-Gated Sodium Channel 1 Subunit GammaScneg |
| Database Links | Reactome: R-MMU-2672351Reactome: -MMU-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Epithelial Sodium Channel Subunit Gamma antibodyAnti-Epithelial Na(+ Channel Subunit Gamma antibodyAnti-Gamma-Enac antibodyAnti-Amiloride-Sensitive Sodium Channel Subunit Gamma antibodyAnti-Gamma-Nach antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Gamma antibodyAnti-Scneg antibodyAnti-Scnn1g antibody |
Information sourced from Uniprot.org
